Chapter 12. Synaptic Integration

  1. Which of the following is not characteristic of central synaptic transmission

    2. a. Convergence
    b. EPSPs about 70 mV amplitude
    c. Both excitation and inhibition
    d. Multiple neurotransmitter receptors
  2. In the spinal reflex arc, both agonistic and antagonistic muscles are inhibited by tendon stretch

    3. a. True
    b. False
  3. Which of these is an excitatory neurotransmitter

    4. a. GABA
    b. Glycine
    c. NMDA
    d. Glutamate
  4. Which of the following does not modulate NMDA receptors

    5. a. Glycine
    b. Magnesium
    c. PCP
    d. Acetylcholine
  5. By which mechanism does GABA inhibit neurons

    6. a. Ionotropic receptors
    b. Metabotropic receptors
    c. Shunting of EPSPs
    d. Only the first two mechanisms
    e. All of the above mechanisms
  6. Missense mutations of the alpha subunit of the glycine receptor cause

    7. a. Excessive benzodiazepine sensitivity
    b. Hyperekplexia
    c. Reduced alertness
    d. Artistic genius
  7. All of these are true of glutamate receptors except

    8. a. They are tetramers
    b. Their subunits have three transmembrane regions
    c. Their voltage sensor is composed of positively charged residues
    d. Some of them bind the synthetic molecule kainate
  8. AMPA receptors lacking GluR2

    9. a. Are calcium permeable
    b. Are not calcium permeable
  9. Synapses on cell bodies are usually

    10. a. Excitatory
    b. Inhibitory

Chapter 13. Modulation of Synaptic Inhibition: Second Messengers

  1. Which of the following are G-protein coupled receptors

    2. a. Adrenergic receptors
    b. Muscarinic receptors
    c. GABA-B receptors
    d. All three
  2. All G protein coupled receptors

    3. a. Have a single subunit with seven membrane-spanning regions
    b. Activate a protein kinase
    c. Activate cAMP
    d. Are hopelessly complicated
  3. G proteins can not

    4. a. Amplify synaptic signals
    b. Directly affect ion channels
    c. Autophosphorylate themselves
    d. Move in the plasma membrane
  4. IP3 and arachidonic acid are generated through the hydrolysis of

    5. a. PIP2
    b. EIEIO
    c. HPETE
  5. The second messenger IP3 releases intracellular stores of

    6. a. Magnesium
    b. Iron
    c. Calcium
    d. Nitrogen
  6. Cytoplasmic guanylyl cyclase is activated by

    7. a. NO
    b. Arachidonic acid
    c. PKC
    d. PKA
  7. It is true that muscarinic receptors can

    8. a. Decrease the M current
    b. Cause hyperpolarization by modulating the M current
    c. Reduce action potential firing by modulating M current
  8. Heart rate slowing with vagal stimulation involves

    9. a. Acetylcholine
    b. G proteins
    c. GIRK
    d. All of the above
  9. Neurotranmitters can alter gene transcription

    10. a. True
    b. False
This is a take-home test due 10/23/01
A score of 80% or better is required.