Chapter 15. Neurotransmitters

  1. Which of the following is a  purinergic transmitter?

    2. a. Glutamate
    b. GABA
    c. Serotonin
    d. ATP
  2. Small-molecule and peptide neurotransmitters differ because

    3. a. Peptide neurotransmitters are not usually packaged in vesicles
    b. Small molecule neurotransmitters are made in presynaptic terminals
    c. Peptide neurotransmitter release does not require calcium
    d. Small molecule neurotransmitters use an exocytotic mechanism
  3. Which of the following is not a peptide neurotransmitters

    4. a. Cardiac intussusception peptide
    b. Substance P
    c. Neuropeptide Y
    d. Vasoactive intestinal polypeptide
  4. Small molecule neurotransmitters and peptide neurotransmitters are often co-released

    5. a. True
    b. False
  5. Removal of neurotransmitter can be accomplished by

    6. a. Diffusion
    b. Uptake
    c. Enzymatic breakdown
    d. All of the above
  6. Fluoxetine blocks uptake of

    7. a. Acetylcholine
    b. Norepinephrine
    c. Serotonin
    d. FMRFamide

Chapter 16. Diseases of Chemical Transmission at the Nerve-Muscle Synapse

  1. Which is not characteristic of myasthenia gravis?

    2. a. Acetylcholine receptor antibodies
    b. Response to thymectomy
    c. Reduced alpha-bungarotoxin binding
    d. All are characteristic
  2. Neonatal myasthenia gravis is different from adult myasthenia gravis because

    3. a. It is not caused by circulating antibodies
    b. It does not respond to plasmapheresis
    c. Thymectomy is not indicated
    d. Weakness is rather mild
  3. Which of the following is found in myasthenia gravis

    4. a. Reduced jitter
    b. Reduced presynaptic acetylcholine content
    c. Reduced end-plate potential amplitude
    d. Reduced calcium channel function
  4. In myasthenia gravis, important factors include

    5. a. Reduced acetylcholine receptor turnover
    b. T cell anergy
    c. Major histocompatibility antigens
    d. All of the above
  5. Match the disease to the pathophysiological substrate (4 points. Draw lines between diseases and substrates.)

    6.  
    Disease Substrate
    Myasthenia gravis Calcium channel antibody
    Slow channel syndrome Acetylcholine receptor antibody
    Botulism Acetylcholine receptor gene
    Lambert-Eaton Syndrome Cleavage of SNAP-25, VAMP and syntaxin
This is a take-home test due 11/06/01
A score of 80% or better is required.