SIU Neurology Resident Neuroscience Course

Chapter 43. The Basal Ganglia

1. List the nuclei of the basal ganglia (4 points)
1. ___________________
2. ___________________
3. ___________________
4. ___________________
2. The striatum consists of (2 points)
1. ___________________
2. ___________________
3. The basal ganglia have their entire output go to thalamus, then to cerebral cortex, so they are involved only in
1. Voluntary movements
2. Oculomotor functions
3. Cognitive functions
4. All of the above
4. Match the pathway to its neurotransmitter (draw a line; 4 points)

Cortex to striatum Striatum to globus pallidus External pallidum to subthalamic nucleus Substantia nigra to striatum

Glutamate GABA Dopamine Neuropeptide Y

5. Parkinsons disease is associated with
1. Overactivity in the direct pathway
2. Overactivity in the indirect pathway
3. Degeneration in the substantia nigra pars recticulata
4. Both A and C
6. Local inhibitory interneurons of the striatum contain primarily
1. Acetylcholine
2. GABA
3. Somatostatin, neuropeptide Y, or nitric oxide synthase
4. Both A and C
7. Activation of the direct pathway leads to
1. Increased firing rate in GPi neurons that discharge tonically at a high rate
2. Reduced firing rate in GPi neurons that discharge tonically at a high rate
3. Activation of the subthalamic nucleus
4. Negative feedback

This is an open-book test due 4/2/2002
A score of 80% or better is required. If your score is less, you are required to retake the test.