SIU Neurology Resident Neuroscience Course

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Chapter 60. Disorders of Thought and Volition: Schizophrenia

  1. Schizophrenia accounts for _______ percent of all hospital admissions.
    1. 1
    2. 5
    3. 10
    4. 30
  2. Approximately ______  percent of the homeless in the U.S. have schizophrenia.
    1. 1
    2. 5
    3. 10
    4. 30
  3. Positive symptoms of schizophrenia include
    1. Flat affect
    2. Psychosis
    3. Lack of motivation
    4. All of the above
  4. Negative symptoms of schizophrenia include
    1. Lack of motivation
    2. Delusions
    3. Hallucinations
    4. All of the above
  5. List three forms of schizophrenia
    1.  _____________________
    2.  _____________________
    3.  _____________________
  6. The strongest predictor of a poor prognosis in shizophrenia is
    1. Poor social development before disease onset
    2. Severity of delusions
    3. Severity of hallucinations
    4. Initial poor response to medication
  7. Schizophrenia has a substantial genetic component due to
    1. Gene mutations
    2. Gene polymorphisms
    3. Dominant inheritance
    4. Recessive inheritance
  8. Which of the following are "atypical antipsychotics"?
    1. Clozapine
    2. Risperdone
    3. Olanzapine
    4. All of the above
  9. Typical antipsychotics bind with high affinity to
    1. D1 receptors
    2. D2 receptors
    3. D3 receptors
    4. D4 receptors
    5. D5 receptors
  10. Atypical antipsychotics bind with high affinity to
    1. D1 and D2 receptors
    2. D2 and D3 receptors
    3. D3 and D4 receptors
    4. D4 and D5 receptors
  11. Antipsychotics bind primarily to
    1. Postsynaptic receptors
    2. Inhibitory autoreceptors
    3. Both
    4. Neither
  12. Which of these dopaminergic systems is most closely related to schizophrenia?
    1. Tuberoinfundibular
    2. Nigrostriatal
    3. Mesolimbic
  13. The mesolimbic dopaminergic system originates in
    1. Sustantia nigra pars compacta
    2. Substantia nigra pars reticulata
    3. Ventral tegmental area
    4. Nucleus accumbens

Chapter 61. Disorders of Mood: Depression, Mania, and Anxiety Disorders

  1. Match the neurotransmitter to the nucleus
Serotonin
Norepinephrine
Dopamine		 Raphe nuclei
Locus ceruleus
Ventral tegmental area
  1. Match the biogenic amine to its precursor
Serotonin
Norepinephrine
Dopamine		 Tryptophan
Tyrosine
L-DOPA
  1. Which of the following are not effective in treatment of depression
    1. Phenelzine
    2. Reserpine
    3. Isoniazid
    4. Fluoxetine
  2. The benefit of lithium is thought to be due to changes in
    1. cAMP
    2. IP3
    3. 5HT3
    4. None of the above
  3. Diagnosis of depression may be helped by the
    1. Dexamethasone depression test
    2. Infusion of sodium lactate
    3. CO2 inhalation
    4. None of the above
  4. Yohimbine (which block alpha-2 adrenergic receptors) may precipitate
    1. Depression
    2. Post-traumatic stress disorder
    3. Panic attacks
  5. Trichotillomania is a distinctive symptom of
    1. Panic attacks
    2. PTSD
    3. Generalized anxiety
    4. OCD


This is an open-book test due 6/4//2002
A score of 80% or better is required. If your score is less, you are required to retake the test.

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